Description
TCR-like monoclonal antibodies (TCR-like mAbs), which recognise a specific peptide in association with an MHC molecule (human leukocyte antigen, HLA in humans), permit the targeting of such inaccessible nuclear or cytoplasmic tumor- or virus-associated antigens based on binding to their MHC-presented peptides found on the surface of target cells. Since they allow, for the first time, visualization of MHC/peptide complexes on various cells in health and disease, they belong to a new class of antibodies which can be utilized as important tools in molecular immunology.
Creative Biolabs has been raised against peptides from many of such antigens. This TCR-like antibody specifically targets to HumanMAGE3 antigen that recognizes epitope FLWGPRALV presented on HLA-A*0201. This product is mainly used to treat Melanoma